Пример #1
0
// AnnotateEnds makes a new 1-base interval for the left and one for the right end
// so that it can use the same machinery to annotate the ends and the entire interval.
// Output into the info field is prefixed with "left_" or "right_".
func (a *Annotator) AnnotateEnds(v interfaces.Relatable, ends string) error {

	var err error
	// if Both, call the interval, left, and right version to annotate.
	if ends == BOTH {
		if e := a.AnnotateOne(v, a.Strict); e != nil {
			err = e
		}
		if e := a.PostAnnotate(v.Chrom(), int(v.Start()), int(v.End()), v.(interfaces.IVariant).Info(), ""); e != nil {
			err = e
		}
		if e := a.AnnotateEnds(v, LEFT); e != nil {
			err = e
		}
		if e := a.AnnotateEnds(v, RIGHT); e != nil {
			err = e
		}
	}
	if ends == INTERVAL {
		err := a.AnnotateOne(v, a.Strict)
		err2 := a.PostAnnotate(v.Chrom(), int(v.Start()), int(v.End()), v.(interfaces.IVariant).Info(), "")
		if err != nil {
			return err
		}
		return err2
	}
	// hack:
	// modify the variant in-place to create a 1-base variant at the end of
	// the interval. annotate that end and then change the position back to what it was.
	if ends == LEFT || ends == RIGHT {
		// the end is determined by the SVLEN, so we have to make sure it has length 1.
		variant := v.(*parsers.Variant).IVariant
		var l, r uint32
		var ok bool
		if ends == LEFT {
			l, r, ok = variant.CIPos()
		} else {
			l, r, ok = variant.CIEnd()
		}
		// dont reannotate same interval
		if !ok && (l == v.Start() && r == v.End()) {
			return nil
		}

		m := vcfgo.NewInfoByte([]byte(fmt.Sprintf("SVLEN=%d;END=%d", r-l-1, r)), variant.(*vcfgo.Variant).Header)
		v2 := parsers.NewVariant(&vcfgo.Variant{Chromosome: v.Chrom(), Pos: uint64(l + 1),
			Reference: "A", Alternate: []string{"<DEL>"}, Info_: m}, v.Source(), v.Related())

		err = a.AnnotateOne(v2, false, ends)
		var val interface{}
		for _, key := range v2.Info().Keys() {
			if key == "SVLEN" || key == "END" {
				continue
			}
			val, err = v2.Info().Get(key)
			variant.Info().Set(key, val)
		}
		err2 := a.PostAnnotate(v.Chrom(), int(l), int(r), variant.Info(), ends)
		if err2 != nil {
			err = err2
		}
	}
	return err
}